Diagnostic Accuracy of Doppler Ultrasound in Diagnosis of Prostatic Neoplastic Etiology Recognizing Histopathology as the Gold Standard

Abstract

Objective: To utilize histopathology as the gold standard, ascertain the diagnostic accuracy of doppler ultrasound inthe detection of prostatic neoplasm utilizing histopathology as gold standard.Methodology: Study was conducted at the Radiology Department Rawalpindi Medical University from 20thSeptember 2021 to 19th February 2022. A cross-sectional descriptive type, consisting of 157 male patients agedbetween 50 to 80 years with elevated prostatic serum antigen (PSA) and prostatomegaly on trans-abdominalultrasonography. Patients, who have previously been diagnosed with prostate cancer, took chemotherapy forprimary or secondary cancers and h/o radiation therapy were excluded. Trans-abdominal gray-scale and dopplerultrasound examinations were performed and gray-scale trans rectal ultrasound (TRUS) was performed on patientswith inconclusive trans-abdominal ultrasound. Representative photos with any focal lesions were recorded. Biopsywas performed with TRUS or transurethral resection of prostate (TURP) and follow up with biopsy report.Results: 80 (True Positive) of the 88 individuals with Doppler USG positivity for prostate cancer had the disease, whileonly 8 (False Positive) did not, according to histopathology. Among 69 patients who tested negative for Doppler USG,13 (False Negative) had prostate cancer on histology, while 56 (True Negative) did not. Sensitivity, specificity, positivepredictive value, negative predictive value, and diagnostic accuracy of conjunct Doppler USG on prostatic lesion wascalculated as 86.02 percent, 87.50 percent, 90.91 percent, 81.16 percent, and 86.62 percent, respectively, usinghistopathology as the gold standard.Conclusion: Doppler ultrasound is the non-invasive modality of preference with excellent diagnostic accuracy foridentifying prostate cancer.Keywords: Doppler Ultrasound; Prostate Cancer; Sensitivit