Autologous fat grafting to the midface and periorbital regions offers a powerful solution for addressing age-related facial volume descent and depletion, contributing to a rejuvenated appearance. Herein, we explore the biological principles of fat grafting, the methodology for harvesting, processing, and injecting fat, and its application in facial aesthetics. We describe the role of different types of autologous fat in restoring volume and improving skin texture and quality. Finally, we discuss the evolving techniques aimed at enhancing graft retention and aesthetic outcomes with a focus on the midface and periorbital regions
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