MATRIX METALLOPROTEINASE 9 GENOTYPE MODULATES ASTHMA CONTROL IN PEDIATRIC ASTHMA PATIENTS

Abstract

Matrix metalloproteinases, particularly MMP9, play a pivotal role in asthma pathology by influencing extracellular matrix remodeling and inflammation. This study examined 100 Serbian pediatric asthma patients to explore the correlation between MMP9 3’ UTR polymorphisms and MMP9 protein levels, and their impact on therapy response and asthma control. The analysis revealed two key polymorphisms (rs13925 and rs20544) in the MMP9 gene's 3’UTR, with higher frequencies of the rs20544 T allele and TT genotype in patients with well controlled asthma. Positive correlations were found between MMP9 serum levels and blood leukocyte count, and CRP levels. Patients with not well controlled disease exhibited significantly higher MMP9 levels than those with well controlled asthma (p=0.027), indicating MMP9's potential role in asthma therapy response