RAW 264.7 Cells Treated with Helichrysum Essential Oil Experience Inhibition of Activation by IFN-γ and LPS

Abstract

In response to excessive cell signaling due to toxicity or harm, cells induce inflammation in the body as a defense mechanism. This inflammation plays a pivotal role in various pathological conditions, ranging from chronic diseases to acute injuries and bug bites. One means of treating inflammation being studied is the use of essential oil and concentrated plant derivatives. Helichrysum essential oil (HEO) is one such oil that has gained attention for its potential anti-inflammatory properties. In our research, we investigate the effects of HEO on inflammation using RAW 264.7 cells as a model for studying macrophage-mediated inflammatory responses. We hypothesize that that the therapeutic introduction of HEO inhibits inflammation as demonstrated in the state of the cell’s size, protein fold change, oxygen consumption, and presence of inflammatory signals. The results could offer valuable insights into the therapeutic potential of HEO and contribute to the development of novel treatments for inflammatory disorders