Association between smoking cessation and risk for type 2 diabetes, stratified by post-cessation weight change: A systematic review and meta-analysis

Abstract

OBJECTIVE: While smoking cessation reduces health risks, its impact on type 2 diabetes mellitus (T2DM) remains complex when considering post-cessation weight gain. This systematic review and meta-analysis examined the association between smoking cessation and diabetes risk stratified by weight change and cessation duration. METHODS: We searched seven databases through April 14, 2025. Observational studies examining smoking cessation, weight changes, and T2DM were included. Random-effects models pooled hazard ratios (HRs) comparing recent and long-term quitters to continuous/never smokers, stratified by weight gain. RESULTS: Among eleven cohort studies, quitters with weight gain showed increased diabetes risk versus continuous smokers (HR = 1.71, 95 % CI: 1.12, 2.62), with recent quitters having greater risk (HR = 2.20, 95 % CI: 1.27, 3.82) but long-term quitters showing reduced risk (HR = 0.91, 95 % CI: 0.87, 0.95). Quitters without weight gain demonstrated no increased risk (recent: HR = 0.99, 95 % CI: 0.81, 1.02) and lower risk (long-term: HR = 0.84, 95 % CI: 0.81, 0.87). Compared to never-smokers, recent quitters had a higher T2DM risk regardless of weight status (with gain: HR = 1.61, 95 % CI: 1.03, 2.50; without gain: HR = 1.25, 95 % CI: 1.05, 1.48), while long-term quitters showed no significant difference. CONCLUSIONS: Smoking cessation temporarily increases T2DM risk, particularly with weight gain, but becomes protective long-term, emphasizing weight management.https://doi.org/10.1016/j.ypmed.2025.10842