Effect of timing of pre-emptive administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal homeostasis, clotting function and perioperative analgesia; a randomised, blinded, controlled clinical trial

Abstract

Please find attached our paper for review entitled 'Effect of timing of pre-emptive 12 administration of meloxicam and robenacoxib for feline ovariectomy on perioperative renal 13 homeostasis, clotting function and perioperative analgesia; a randomised blinded controlled 14 clinical trial'. We thank you in advance for reviewing our manuscript. We can confirm that 15 this work is unpublished and is not being submitted for publication elsewhere at the same 16 time. We (the authors) have agreed with the submission in its present form. 17 We believe this work to be of high significance. To our knowledge, this is the first 18 randomised, blinded controlled clinical trial in cats investigating the effect of timing on renal 19 homeostasis, clotting function and perioperative analgesia around neutering in veterinary 20 medicine. We hope that this will provide some evidence-based recommendations for our 21 colleagues in primary and referral practice and provide a stimulus for further publications 22 around this common place procedure. More importantly, we hope this will improve analgesia 23 recommendations and therefore animal welfare globally. 24 This publication is necessary for the submission of college credentials of the first author. 25 These are due in August 2023, and although it leaves 9 months between submission and 26 hopefully acceptance, we would be very grateful for the help you could provide in facilitating 27 timely review. Hopefully, this leaves enough time. 28 Thank you again for reviewing our submission and please don't hesitate to contact us if you 29 have any further queries. 30 Yours sincerely