Dataset for "MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage"

Abstract

This dataset supports the publication titled “MRN-CtIP, EXO1, and DNA2-WRN/BLM act bidirectionally to process DNA gaps in PARPi-treated cells without strand cleavage,” published in Genes & Development. It contains data from a range of experimental approaches, including single-molecule DNA fiber analysis, immunofluorescence, flow cytometry, electron microscopy, metaphase spread assays, and biochemical analyses. All cellular assays were conducted in human cell lines, while biochemical experiments used purified proteins from both human and yeast sources. The complete dataset is approximately 88 GB in size and includes 66,960 files organized into two main folders. The Figures folder contains 44,103 files across 1,651 subfolders and is 69.4 GB in size. The Supplemental Figures folder contains 22,805 files across 880 subfolders and is 18.7 GB