High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment

Ranganathan, Uma Devi; Smith-Jeffcoat, SE; Balaji, S; Devika, K; Nair, Dina; Daniel, Bella Devaleenal; Srinivasan, R; Baskaran, M; Ravikumar, D; Sangamithirai, D; Radhika, Golla; Mangalambal, G; Lavanya, J; Maheswaran, K; Kumar, S; Sridhar, R.; Tripathy, S; Swaminathan, S; Eisenach, K D; Cegielski, J P

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oai:eprints.nirt.res.in:2051

High-dose isoniazid for TB with low-to-moderate isoniazid resistance after 1 week of treatment

Authors: Uma Devi Ranganathan
SE Smith-Jeffcoat
S Balaji
K Devika
Dina Nair
Bella Devaleenal Daniel
R Srinivasan
M Baskaran
D Ravikumar
D Sangamithirai
Golla Radhika
G Mangalambal
J Lavanya
K Maheswaran
S Kumar
R. Sridhar
S Tripathy
S Swaminathan
K D Eisenach
J P Cegielski
Publication date: 1 June 2025
Publisher
Doi

Abstract

To evaluate the effect of high-dose isoniazid in patients with isoniazid-resistant TB by its bactericidal activity after 1 or more weeks of treatment.Using the rapid direct method of phenotypic drug susceptibility testing, we screened persons with positive sputum microscopy results and genotypic drug resistance for isoniazid resistance.Those with no growth at a critical concentration of 2.0 mg/L were invited to participate in a trial of high-dose isoniazid monotherapy lasting 6 days. After 3 days of no treatment, patients received isoniazid 15 mg/kg and were followed with serial quantitative sputum cultures from Days 0 to

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oai:eprints.nirt.res.in:2051

Last time updated on 21/09/2025

This paper was published in NIRT Institutional Repository.

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