The Mediterranean region faces significant challenges within the Water-Energy-Food-Ecosystem (WEFE) Nexus due to water scarcity, increasing agricultural and energy demands, and ecosystem degradation exacerbated by climate change. This research addresses these challenges by integrating two water footprint (WF) methodologies, the volumetric Water Footprint Assessment (WFA) and the impact-oriented Water Scarcity Footprint (WSF) and then correlating the results with the WEF Nexus Index and other sustainability indicators, to explore trade-offs and synergies across water, energy, food, and ecosystem dimensions at multiple scales. Findings highlight that the most significant impacts of water consumption stem from the cultivation of water-intensive crops in water-scarce regions, both within and beyond the Mediterranean. This underscores the pivotal role of virtual water trade and the global implications of local water management practices. The results further reveal critical disparities in water resource use and stress among Mediterranean countries, emphasizing the need for targeted policy interventions and international cooperation to address these challenges. By elucidating the interdependencies between water and the other WEFE Nexus dimensions, this study contributes valuable insights for policymakers, researchers, and stakeholders striving to achieve sustainable resource management and resilience in the Mediterranean region and beyond.Peer ReviewedPostprint (published version
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