Bipolar Disorder Among Individuals With Atopic Dermatitis: A Case-Control Study In The All Of Us Research Program

Abstract

Background: Atopic dermatitis has been associated with psychiatric comorbidities.Objectives: To characterize the association between atopic dermatitis and bipolar disorder with a case-control study of the NIH All of Us Research Program. Methods: Utilizing Systemized Nomenclature of Medicine diagnostic codes, we identified cases of atopic dermatitis. Four age, sex, and race/ethnicity matched controls were found for each case using propensity score matching. After controlling for age, sex, race/ethnicity, income, smoking status, and depression, the relationship between atopic dermatitis and bipolar disorder was evaluated using logistic regression. Results: We identified 13,431 atopic dermatitis cases with 53,724 matched controls. Participants with atopic dermatitis were more likely than controls to have bipolar disorder (7.8% vs. 4.6%, P\u3c.001). After adjusting for demographics and comorbidities, we observed a significant association between atopic dermatitis and bipolar disorder (odds ratio 1.49, 95% confidence interval 1.37-1.62, P\u3c.001). Conclusion: Compared to individuals without atopic dermatitis, individuals with atopic dermatitis have 1.49-fold increased odds of having bipolar disorder. Further investigation is needed to further understand this association