Tuning electronic and steric properties of diphosphines: synthesis and characterization of Ph₂PCHRPPh₂ variants

Abstract

Under the direction of Dr. Daniel Derringer This study explores the synthesis and characterization of diphosphines of the type Ph₂PCHRPPh₂, focusing on the variability of the R group to tune electronic and steric properties. We have successfully synthesized and analyzed Ph₂PCH(CN)PPh₂ and Ph₂PCH(CH₃)PPh₂, demonstrating significant differences in their electronic and steric profiles. Building on this foundation, we aim to synthesize Ph₂PCH(CCl₃)PPh₂, hypothesizing that the introduction of the CCl₃ group will further modulate the ligand\u27s properties. Preliminary results indicate promising pathways for the synthesis of Ph₂PCH(CCl₃)PPh₂, which could offer unique advantages in coordination chemistry and catalysis. Further studies will focus on optimizing the synthesis process and evaluating the ligand\u27s performance in various catalytic applications