Characterization of VitE-TPGS Micelles linked to Poorly Soluble Compounds for Pharmaceutical Applications exploiting the Pair Distribution Function’s Moments

Abstract

no final abstract yet. Draft: We introduce an innovative theoretical framework tailored for the analysis of Pair Distri�bution Function (PDF) data derived from Small-Angle X-ray Scattering (SAXS) measurements of core-shell micelles. The new approach involves the exploitation of the first derivative of the PDF and the derivation of analytical equations to solve the core-shell micelle structure under the hypothesis of a spheroidal shape. These analytical equations enable us to determine the micelle’s aggregation number, degree of ellipticity, and contrast in electron density between the core-shell and shell-buffer regions after having determined the whole micelle size and its shell size from the analysis of the first derivative of the PDF