Comparing the Efficacy of CBD and NSAIDs in Recovery from Delayed Onset Muscle Soreness Following Eccentric Exercise: A Systematic Review

Abstract

Objective: To compare the effectiveness of cannabidiol (CBD) and nonsteroidal anti-inflammatory drugs (NSAIDs) in treating delayed onset muscle soreness (DOMS) following eccentric exercise. Methods: Literature was gathered through PubMed, Medline, and Science Direct in January and February 2025. Randomized controlled trials examining CBD or NSAIDs for DOMS were selected. Nine studies met the inclusion criteria. Results: Five CBD studies reported no significant improvements in soreness, inflammation, or recovery compared to placebos. One study showed slight soreness reduction at 48 hours but no functional benefits. All three NSAID studies showed short-term pain relief, particularly within 24 hours, but no improvements regarding long-term muscle recovery. Conclusions: CBD does not currently demonstrate effectiveness in treating DOMS. NSAIDs may offer short-term pain relief, but neither intervention significantly improves long-term recovery outcomes. Further research is needed to evaluate optimal dosing and alternative treatments for DOMS