The Genetic Role of Necrotizing Fasciitis

Abstract

This project investigated the possible role of the GAS6 gene (chromosome 13, long arm cytogenetic band 4) regarding increased susceptibility to necrotizing fasciitis, a dangerous soft tissue infection. GAS6 encodes a ligand for TAM receptors known as Mer, Axl, and Tyro3. These regulate the immune system in matters such as inflammatory and immune responses. Issues with immune activation caused by dysfunction of TAM signaling could be a potential cause of tissue damage in necrotizing fasciitis. Overall, the study analyzed the possible genetic predisposition individuals may possess that would make them more vulnerable to acquiring necrotizing fasciitis in particularly sterile environments. Thus, highlighting the need for future research into the effect of genetic risk factors influencing inflammatory pathways and the coinciding results