Tubulin targeting agents and their implications in non-cancer disease management

Abstract

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Microtubules act as molecular ‘‘tracks’’ for intracellular transport of accessory proteins to enable them to assemble into various larger structures, such as spindle fibers formed during the cell cycle. Microtubules provide an organizational framework for healthy functioning of various cellular processes which work through the process of dynamic instability, driven by hydrolysis of GTP. In their role, tubulin proteins undergo various modifications and in doing so modulate various healthy or pathogenic functioning of physiological processes within cells. In this review, we provide a detailed update of small molecule chemical agents which interact with tubulin, along with their implications, specifically in non-cancer disease management