Retinal vasculometry associations with cognition status in UK Biobank

Shakespeare, Royce; Rudnicka, Alicja R.; Welikala, Roshan; Barman, Sarah A.; Khawaja, Anthony P.; Foster, Paul J.; Owen, Christopher G.; UK Biobank Eye and Vision Consortium

oai:eprints.kingston.ac.uk:56896

Retinal vasculometry associations with cognition status in UK Biobank

Authors: Royce Shakespeare
Alicja R. Rudnicka
Roshan Welikala
Sarah A. Barman
Anthony P. Khawaja
Paul J. Foster
Christopher G. Owen
UK Biobank Eye and Vision Consortium
Publication date: 24 February 2025
Publisher: Wiley
Doi

Abstract

Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale. One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance

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Last time updated on 27/03/2025

This paper was published in Kingston University Research Repository.

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