Sicily, an island rich in history and tradition, is renowned for its unique viticultural
landscape, where native vines have been cultivated for centuries. The commercial
value of Sicilian wines is rooted in their distinctive flavors and aromas and the cultural
heritage they embody. This paper delves into the characterization of native Sicilian wines
according to their phenolic contents, antioxidant activity, and chemometrics. Nero d’Avola
and Syrah showed the highest phenolic content and the highest antioxidant activity. Among
the white wines, the Catarratto and Zibbibo samples were richer in antioxidants than the
Grillo ones. In the Principal Component Analysis, it was possible to note the grouping
of the red and white wines in the first component and an early grouping according to
variety in the second one. Furthermore, the variable examined allowed for a suitable
classification model (up to 83%) to be built for the Nero d’Avola, Syrah, Grillo, and Zibibbo
wines through a Linear Discriminant Analysis. The findings highlight how these phenolic
profiles contribute to the distinctiveness and marketability of Sicilian wines, offering a
deeper appreciation of their value within the global wine industry
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