Multicomponent signals play a key role in many application fields, such as biology, audio processing, seismology, air traffic control and security. They are well represented in the time-frequency plane where they are mainly characterized by special curves, called ridges, which carry information about the instantaneous frequency (IF) of each signal component. However, ridges identification usually is a difficult task for signals having interfering components and requires the automatic localization of time-frequency interference regions (IRs). This paper presents a study on the use of the frequency parameter of a hyperbolic-polynomial penalized spline (HP-spline) to predict the presence of interference regions. Since HP-splines are suitably designed for signal regression, it is proved that their frequency parameter can capture the change caused by the interaction between signal components in the time-frequency representation. In addition, the same parameter allows us to define a data-driven approach for IR localization, namely HP-spline Signal Interference Detection (HP-SID) method. Numerical experiments show that the proposed HP-SID can identify specific interference regions for different types of multicomponent signals by means of an efficient algorithm that does not require explicit data regression
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