Clinical and Laboratory Characteristics and effect of Smoking Cessation on WBC and platelet indices: a retrospective study

Abstract

DOI: 10.5281/zenodo.11144421 The aim of this study was to assess the values of mean platelet volume (MPV) in regular smokers and the effect of smoking cessation on WBC and MPV. The study included 46 regular smokers (mean age: 36.4 + 9.6 years). Smokers were chosen among those who had visited a smoking cessation outpatient clinic from August 2021 through March 2022. 40 out of 46 frequent smokers were successful in quitting. Platelet indices, including MPV, platelet count, platelet distribution width (PDW), and white blood cell (WBC) count, were assessed per months following smoking cessation in 40 subjects and compared to their baseline platelet indices. There were no statistically significant differences between the Smoker and control groups with respect to age, gender, BMI19.2/20.9, SBP 132/129.9, DBP 79.6/78.3 and levels of glucose higher in smoker group (102.8 ± 10.3/96.3 ± 10.9), creatinine 0.91±0.11 / 0.8 ± 0.2, total cholesterol 186.2 ± 36.9/196.5 ± 21.3, triglyceride 147.7±78.2/150.3 ±  73.8, low-density lipoprotein (LDL) cholesterol 111.6±39.2/123.8 ± 30.6, high-density lipoprotein (HDL) cholesterol 42.9±10.0/45.9 ± 9.6, WBC 5.99±7.2/5.62 ±6.50, haemoglobin 14.9±1.0/14.2±1.5, The MPV values were significantly higher in smokers than those of controls (8.02 ± 0.72/7.50 ± 0.32) and PDW 15.1±1.3/15.2±1.6. Platelet count was higher in the control group 225.6 ± 32.0 than Smoker group 191.9 ± 40.2 but the difference did not reach a statistically significant level. By emphasizing the connection between smoking, platelet activation, and cardiovascular diseases, can contribute to increasing the motivation for smokers to make the decision to quit and ultimately improve their overall health and well-being.