Search for new unti-diabetic medicine from functional foods through the reduction of liver fat

Abstract

研究代表者連携研究者publisher研究種目：基盤研究(C); 研究期間：2012～2014; 課題番号：24590153; 研究分野：生薬学, 食品薬学, 薬理学; 科研費の分科・細目：研究成果の概要（和文): 本研究では, 既存医薬品の作用機序とは異なり, 肝臓中の中性脂肪含量の低減を介して, 肝臓による糖取り込み能の亢進によってもたらされる血糖値改善作用物質を探索した. その成果として, 報告者はタイ産のフタバガキ科植物Shorea roxburghii 樹皮からスチルベンオリゴマー (-)-hopeaphenol や (+)-isohopeaphenol, ベンケイソウ科植物 Sedum sarmentosumより, flavonol 配糖体 sarmenoside 類, エジプト産ブラッククミン (Nigella sativa 種子) から nigellamine A5 などを明らかにした. 研究成果の概要（英文): From a series of search for anti-diabetic compounds from functional foods, several compounds which reduced contents of triglyceride (TG) in hepatocytes were found. Through the period of this study, (-)-hopeaphenol from burk of Shorea roxbughii, sarmenosides from aerial parts of Sedum sarmentosum, nigellamines from seeds of Nigella sativa, and flavonol glycosides from Rosa canina and Camellia sinensis were elucidated as bioactive compounds which reduced TG contents in hepatocytes. Moreover, reduction of liver TG in mice was observed in vivo studies through the oral administration of several extracts