A Clinical study on Effect of Platelet Rich Plasma on Wound Healing in Patients Undergoing Modified Radical Mastectomy

Abstract

BACKGROUND AND OBJECTIVES: Breast cancer forms more than thirty three percent of all malignancy affecting women and for twenty percent of cancer related deaths in women. The standard of therapy for the majority of patients with invasive breast cancer is still complete breast excision along with axillary lymph node dissection. Seroma development might occur anywhere from 5% to 85% of the time. Seroma can increase morbidity, lengthen hospital stays, necessitate multiple aspirations, cause wound gaping and erythema, and delay chemotherapy and radiotherapy cycles, among other things. To evaluate using platelet rich plasma in a prospective randomised controlled manner, the decrease in the incidence of seroma formation among patients subjected to modified radical mastectomy. METHOD: A total of 90 Carcinoma Breast who underwent Modified Radical Mastectomy in the Institute of General Surgery, Madras Medical College, Chennai, were in included in this prospective study and randomised into two groups based on in-patient number. 45 patients with odd IP no in Group A received Platelet Rich Plasma injections and 45 patients with even IP no in Group B did not receive any topical treatment. Patients were evaluated for day 1 drain volume, total drain volume, drain removal day, seroma, and wound complications using REEDA score Vancouver Scar Scale. RESULTS: The mean seroma formation on post-operative day one was 141.11 ml in PRP group and 162.33 ml in control group and there is a statistically significant association between PRP injection and seroma formation. There was also statistically significant association between PRP injection and total seroma formation and day of drain removal. In our study wound healing was also observed using two parameters REEDA score and VSS. CONCLUSION: The most common complication following modified radical mastectomy is seroma formation and the present prospective study demonstrated that local injection of Platelet Rich Plasma significantly decreased the seroma formation and favours wound healing