Aktivitas Antibakteri dan Toksisitas Kerang Balelo Segar (Conomurex sp.)

Abstract

Conus clams or balelo clams are molluscs which are quite abundant in tropical waters. Several types of bioactive compounds in balelo shells are alkaloids, flavonoids, tannins, saponins, steroids and phenol hydroquinones. In several studies, this type of mollusc has potential as a nutraceutical or pharmaceutical use. The purpose of this study was to analyze the antibacterial activity and toxicity of the Brine Shrimp Lethality Test (BSLT) method of wet extracts of balelo shells (Conomurex sp.) in vitro using 3 types of solvents namely methanol, ethyl acetate and n-hexan. The research method consisted of two stages, namely the first stage of characterization which included sample preparation and extraction process using n-hexane, ethyl acetate and ethanol, the second stage was testing the antibacterial and toxicity of fresh balelo shell extract. The results showed that fresh balelo mussels in methanol, ethyl acetate, and n-hexan extracts had antibacterial activity with an inhibition zone of 6 mm against E. coli and S. aureus  bacteria, and the toxicity value or LC50 value of the methanol extract was 226.47 ?g/mL, ethyl acetate was 640.46 ?g/mL and n-hexan was 195.53 ?g/mL, this indicated that the mussels Fresh balelo is toxic.