Apoptosis and autophagy inhibited by autophagy-related circular RNA in Schwann cells via miR-144-3p/PI3K/AKT/mTOR pathway: DOI: 10.14800/rd.461

Abstract

Diabetic peripheral neuropathy is a common complications of Type 2 Diabetes and its main pathological feature is myelin sheath damage of peripheral nerve that was induced by Schwann cells (SCs) apoptosis. Increasing evidence suggested that noncoding RNAs might play a role in improving DPN because of its ability to prevent SCs apoptosis. In this study, we explore the effect of autophagy-related circular RNA on preventing SCs apoptosis and its underlying mechanism. Our study found that ACR could relieve HG-aroused RSC96 cell apoptosis, autophagy, and oxidative stress via reducing miR-144-3p and then promoting PI3K/AKT/ mTOR pathway activation, which provides some clues that ACR might be effective and feasible candidate for the treatment of DPN