Understanding the mechanism of cardiac gene remodelling via PPAR-α signalling in cardiac hypertrophy

Abstract

identified and unveiled the functional relevance of differentially expressed miRNAs in ISO-treated PPAR α-/- mice. As of now, limited literature was available about miRNA abundance and their altered expression in cardiac hypertrophy models in the absence of PPAR α protein. So for the very first time, using PPAR α-/- mice, we showed that several miRNAs are differentially expressed that have never been reported in context to cardiac hypertrophy. Additionally, pathway analysis, indicated that the dysregulated miRNAs target genes were enriched mostly in signal transduction pathways. Overall, our findings suggest the miRNAs expression profile of miRNAs like mmu-miR3102-5p; mmu-miR-30a-5p; mmu-miR-30c-5p; mmu-miR-466i-5p is significantly altered in response to cardiac hypertrophy in PPAR-/- mice that eventually impacts the apoptotic pathway in a negative manner