Iodine Catalyzed one-Pot Four Component Synthesis of Coumarinyl Phosphoramidates via Sequential Addition of Reactants

Abstract

An unprecedented synthetic route for the preparation of a library of novel coumarinyl phosphoramidate derivatives via iodine catalysed one-pot four component reactions of ethyl 4-bromo-3-oxo-alkanoate, sodium azide, trialkyl phosphites, and phenols in the ethanol solvent is reported here. The reaction proceeds via the nucleophilic substitution reaction, phosphoramidate rearrangement and Pechmann cyclization with C-C, C-O, C-N and N-P bond formation. The prominent features of this procedure are simple one-pot operation, cost effective, non-toxic and excellent yields of the products