Poor correlation between 6β-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity

Chen, Ya Chi; Gotzkowsky, S. Karl; Nafziger, Anne N.; Kulawy, Robert W.; Rocci Jr., Mario L.; Bertino Jr., Joseph S.; Kashuba, Angela D.M.

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cdr.lib.unc.edu:ng451q652

Poor correlation between 6β-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity

Authors: Ya Chi Chen
S. Karl Gotzkowsky
Anne N. Nafziger
Robert W. Kulawy
Mario L. Rocci Jr.
Joseph S. Bertino Jr.
Angela D.M. Kashuba
Publication date: 1 January 2006
Publisher
Doi

Abstract

A non-invasive proposed method for measuring CYP3A activity is the urinary 6β-hydroxycortisol:cortisol ratio. This ratio has been used as an indicator of CYP3A induction and inhibition, with mixed results. This investigation evaluated the relationship between a validated, biomarker, intravenous midazolam clearance and the urinary cortisol ratio under constitutive conditions and with the influence of a moderate CYP3A inhibitor

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cdr.lib.unc.edu:ng451q652

Last time updated on 24/11/2020

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