TNIK (TRAF2 and NCK interacting kinase)

Abstract

The serine/threonine kinase Traf2- and Nck interacting kinase (TNIK), is a member of the germinal center kinase (GCK) family that has been reported to have an important role in the regulation of Jun N-terminal kinase pathway (JNK) activation and actin cytoskeleton. It has also been demonstrated that TNIK is an important activator of Wnt pathway, where it interacts with β-catenin/TCF4 complex, phosphorylates Tcf4 inducing the transcription of Wnt target genes. In several studies, the expression of TNIK has been established to be involved in different human cancers