Yellow fever virus modulates cytokine mRNA expression and inducesactivation of caspase 3/7 in the human hepatocarcinoma cell lineHepG2

Abstract

AbstractYellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly theliver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokinesand the activation of caspases in HepG2 cells infected with YFV. We observed that interferon-? (IFN-?) expression decreasedand IFN-?, transforming growth factor (TGF)-? IIIR, interleukin (IL)-6, and IL-8 expression increased in cells infected withgenotype 1. In contrast, TNF-? expression increased in cells infected with genotype 2 but not with genotype 1. This providesinsights into the role of cytokine regulation in yellow fever