Thailand orthohantavirus infection in patients with chronic kidneydisease of unknown aetiology in Sri Lanka

Abstract

AbstractChronic kidney disease of unknown aetiology (CKDu) reported in Sri Lanka and other countries is a mysterious and seriousdisease. Recently, we reported a high seroprevalence of antibodies to a hantavirus antigen among CKDu patients inGirandurukotte, Badulla district, Sri Lanka. However, the type of hantavirus with which the residents were infected was notdetermined. In this study, a total of 89 seropositive sera were examined to identify their serotypes using an indirect immunofluorescentantibody assay, a truncated-N-protein-based enzyme-linked immunosorbent assay, and a cross-neutralizationtest. These results indicated that the residents in this area were frequently infected with Thailand orthohantavirus or anantigenically related virus