research article
BUB3 (BUB3 mitotic checkpoint protein)
Abstract
BUB3 is a WD40 protein that belongs to spindle mitotic checkpoint complex, which monitors the chromosome attachment to mitotic (or meiotic) fuse and prevents premature chromosome segregation. Alterations in BUB3 have been associated with chromosomal instability and aneuploidy, but their contribution for cancer development and progression are poorly understood, and appear to differ depending on the type of cancer. The present review contains data on BUB3 DNA, RNA, protein encoded and function- Article
- BUB3
- Mitotic checkpoint protein BUB3
- WD40 protein
- Spindle checkpoint
- Cell cycle
- Anaphase-promoting complex
- Genes Section
- Animals
- Apoptosis/genetics
- Cell Cycle Proteins/*antagonists & inhibitors/genetics/metabolism
- Cell Line, Tumor
- DNA Methylation
- Heterografts
- Humans
- Male
- Mice
- Mice, Nude
- Mitosis/genetics/*physiology
- Pancreatic Neoplasms/genetics/*metabolism/pathology
- Phosphorylation
- Poly-ADP-Ribose Binding Proteins/*antagonists & inhibitors/genetics/metabolism
- Repressor Proteins/*antagonists & inhibitors/genetics/metabolism
- Signal Transduction
- Transcription, Genetic
- src-Family Kinases/genetics/*metabolism
- BRCA1 Protein/*genetics
- Cell Cycle Proteins/genetics
- Chromosomes/genetics
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This paper was published in I-Revues.
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