research article
CRLF2 (Cytokine receptor like factor 2)
Abstract
CRLF2 is a member of type I cytokine receptor family. CRLF2 forms a functional complex with IL-7 receptor α chain and thymic stromal lymphopoietin, this complex induces the activation of signal transducers and activators of transcription proteins. The overexpression of CRLF2 induced by genetic rearrangements has been described in acute lymphoblastic leukemia- Article
- CRLF2
- Cytokine receptor
- TSLP
- Jak-Stat pathway
- Genes Section
- *Adaptive Immunity
- Asthma/*immunology
- Child
- Cytokines/*metabolism
- Humans
- *Immunity, Innate
- Models, Biological
- Receptors, Cytokine/*metabolism
- Cytokines/chemistry/*metabolism
- Drug Evaluation, Preclinical
- Humans
- Molecular Docking Simulation
- Protein Binding/drug effects
- Protein Conformation
- Receptors, Cytokine/chemistry/*metabolism
- Th2 Cells/drug effects/metabolism
- User-Computer Interface
- Asymptomatic Diseases
- Child
- Child, Preschool
- Chromosomes, Human, X/*chemistry
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This paper was published in I-Revues.
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