Pyrazole‐Derived Ligands In Palladium‐ Catalyzed Reactions

Abstract

In chapter 1, the General background, we have briefly discussed about pyrazole tethered ligands, Palladium as catalyst and pyrazole ligands in palladium catalysis. In chapter 2, a pyrazole tethered pyridine ligand assisted Pdcatalyzed addition reaction of arylboronic acids to aryl aldehydes has been described and it has also been demonstrated that the reaction medium plays a decisive role in determining product formation. In chapter 3, synthesis of some pyrazole tethered pyridine ligands and their utility in Pd and Cu‐catalyzed addition reaction of arylboronic acids to nitriles and palladium catalyzed addition of free (N‐H) indoles to nitriles has been presented. In chapter 4, use of pyrazole tethered imino phenolate ligand in palladium catalyzed Suzuki‐Miyaura cross‐coupling reaction of bromo and chloroarenes and oxidative Heck reaction has been presented. In chapter 5, a new camphor based, pyrazole‐tethered chiral P, N ligand assisted Palladium catalyzed asymmetric alkylation, amination and asymmetric Suzuki‐Miyaura cross‐coupling reaction has been performed. In keeping with the general practice of reporting scientific observations, due acknowledgements have been made to the findings of other investigators. The responsibility of any unintentional oversight is solely mine.The research was conducted under the supervision of Prof. Amitava Sarkar, Organic Chemistry division under SCS [school of Chemical Sc]The research was conducted under CSIR fellowshi