一种水凝胶及其制备方法
Abstract
本发明提供了一种水凝胶,由载药颗粒、具有式II所示结构的改性壳聚糖、包括式III和式IV所示结构嵌段的聚-γ-谷氨酸星型嵌段共聚物、包括式V和式VI所示结构嵌段的聚-L-赖氨酸星型嵌段共聚物和溶剂制备得到；所述载药颗粒由具有式I所示结构的改性葡聚糖和药物制备得到。本发明提供的水凝胶是基于静电作用和席夫碱键交联的水凝胶,通过将物理静电作用和席夫碱键化学交联相结合,使本发明提供的水凝胶强度较高而且稳定性好,能够满足临床注射的要求,而且其中的载药颗粒作为化学交联剂,能够使水凝胶中药物缓慢释放,实现药物在病灶部位的靶向释放和富集,从而提高药物的治疗效果。本发明还提供了一种水凝胶的制备方法Similar works
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Last time updated on 13/03/2018
This paper was published in Changchun Institute of Applied Chemistry, Chinese Academy Of Sciences.
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