oaioai:ir.ciac.jl.cn:322003/78201

一种用WS2纳米片抑制Aβ聚集的方法并解聚已形成的Aβ纤维聚集体的方法

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Publication date
26 March 2015
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Abstract

本发明提供一种用WS2纳米片抑制Aβ聚集的方法并解聚已形成的Aβ纤维聚集体的方法,属于医药技术领域。该方法利用过渡金属二硫化钨二维纳米材料抑制Aβ的聚集,WS2纳米片能够通过其平面基底与芳香族氨基酸之间的范德华力吸附Aβ单体,同时,WS2表面带负电,可以静电结合Aβ的阳离子簇区域,增强Aβ单体与WS2片层结构间的结合,抑制Aβ聚集；本发明还提供一种用WS2纳米片解聚已形成的Aβ纤维聚集体的方法,WS2纳米片具有明显的光热效果,在近红外光照射下能够有效的光热解聚已形成的Aβ纤维聚集体；同时,WS2纳米片可以降低Aβ引起的细胞毒性

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Changchun Institute of Applied Chemistry, Chinese Academy Of Sciences

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oaioai:ir.ciac.jl.cn:322003/78201
Last time updated on 13/03/2018

This paper was published in Changchun Institute of Applied Chemistry, Chinese Academy Of Sciences.

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