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Changing dynamics of spontaneous waves during retinal development: a novel panretinal perspective achieved with the Active Pixel Sensor (APS) 4,096 electrodes array

By Matthias Hennig, Evelyne Sernagor, Alessandro Maccione, Mauro Gandolfo, Stephen Eglen and Luca Berdondini

Abstract

The developing retina exhibits spontaneous waves of activity spreading across the ganglion cell layer. These waves are present only during a limited perinatal period, and they are known to play important roles during the wiring of visual connections. Using the APS MEA devices consisting of 4,096 electrodes recording at near cellular resolution, we have been able to achieve panretinal recordings of retinal waves in the neonatal mouse retina. We found that the spatiotemporal patterns of the waves undergo profound developmental changes as retinal synaptic networks mature, switching from slow random events propagating over large retinal areas to faster, spatially more restricted events, following several clear repetitive, non-random propagation patterns. This novel panretinal perspective of wave dynamics provides new clues about the role played by retinal waves during visual map formation

Year: 2010
OAI identifier: oai:www.era.lib.ed.ac.uk:1842/4211

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Citations

  1. Emergence of sustained spontaneous hyperactivity and temporary preservation of OFF responses in ganglion cells of the retinal degeneration (rd1) mouse. doi
  2. Microelectronic system for high-resolution mapping of extracellular electric fields applied to brain slices. doi
  3. Parallel processing in the mammalian retina. doi
  4. (2010). Retinal Signalling 7th Int. Meeting on Substrate-Integrated Microelectrode Arrays,

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