This paper summarizes key advances in hypnosis research during the past two decades,
including (1) clinical research supporting the efficacy of hypnosis for managing a number of
clinical symptoms and conditions, (2) research supporting the role of various divisions in the
anterior cingulate and prefrontal cortices in hypnotic responding, and (3) an emerging finding
that high hypnotic suggestibility is associated with atypical brain connectivity profiles. Key
recommendations for a research agenda for the next decade include the recommendations that (1)
laboratory hypnosis researchers should strongly consider assessing hypnotic suggestibility in
their studies, (2) inclusion of study participants who score in the middle range of hypnotic
suggestibility, and (3) use of expanding research designs that more clearly delineate the roles of
inductions and specific suggestions. Finally, we make two specific suggestions for helping to
move the field forward including (1) the use of data sharing and (2) redirecting resources away
from contrasting state and non-state positions toward studying (a) the efficacy of hypnotic
treatments for clinical conditions influenced by central nervous system processes and (b) the
neurophysiological underpinnings of hypnotic phenomena. As we learn more about the
neurophysiological mechanisms underlying hypnosis and suggestion, we will strengthen our
knowledge of both basic brain functions and a host of different psychological functions
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