Skip to main content
Article thumbnail
Location of Repository

Variable renewal rate and growth properties of cell populations in colon crypts

By A Di Garbo, M. D. Johnston, S. J. Chapman and P. K. Maini


A nonlinear mathematical model is used to investigate the time evolution of the cell populations in colon crypts (stem, semidifferentiated and fully differentiated cells). To mimic pathological alteration of the biochemical pathways leading to abnormal proliferative activity of the population of semidifferentiated cells their renewal rate is assumed to be dependent on the population size. Then, the effects of such perturbation on the population dynamics are investigated theoretically. Using both theoretical methods and numerical simulations it is shown that the increase in the renewal rate of semidifferentiated cells strongly impacts the dynamical behavior of the cell populations

Topics: Biology and other natural sciences
Publisher: American Physical Society
Year: 2010
DOI identifier: 10.1103/PhysRevE.81.061909
OAI identifier:

Suggested articles

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.