Location of Repository

Role of splice variants in the metastatic progression of prostate cancer

By R. M. Hagen and M. Ladomery

Abstract

AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over\ud the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice\ud variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately altering\ud metastatic potential. As metastases are the cause of approximately 90% of all human cancer deaths, it is\ud crucial to understand how AS is dysregulated in metastatic disease. We highlight some recent studies into\ud the relationship between altered AS of key genes and the initiation of prostate cancer metastasis

Publisher: Portland Press
Year: 2012
OAI identifier: oai:eprints.uwe.ac.uk:17489

Suggested articles

Preview


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.