In this paper, we interpret the 750 GeV diphoton excess in the Zee–Babu extension of the two-Higgs-doublet model by introducing a top partner (T)/bottom partner (B). In the alignment limit, the 750 GeV resonance is identified as the heavy CP-even Higgs boson (H), which can be sizably produced via the QCD process pp→TT¯ or pp→BB¯ followed by the decay T→Ht or B→Hb. The diphoton decay rate of H is greatly enhanced by the charged singlet scalars predicted in the Zee–Babu extension and the total width of H can be as large as 7 GeV. Under the current LHC constraints, we scan the parameter space and find that such an extension can account for the observed diphoton excess
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