Brugada syndrome: Recent understanding of pathophysiological mechanism and treatment

Abstract

Since 1992, Brugada syndrome has gained worldwide recognition as an important cause of sudden cardiac death due to ventricular fibrillation (VF) in the structurally normal heart. Its signature electrocardiography (ECG) pattern consists of ST-segment elevation in the right precordial leads, and the pathophysiological mechanisms of this ST-segment elevation and VF development have been reported to be closely related. However, the precise mechanisms present in Brugada syndrome patients remain unknown. Herein, we will review clinical and experimental evidence, with a focus on the current understanding of the underlying pathophysiological mechanisms of this unique ECG pattern and VF development, and describe the current strategy for management of Brugada syndrome