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Uner Tan Syndrome: History, Clinical Evaluations, Genetics, and the\ud Dynamics of Human Quadrupedalism

By Prof. Dr. Uner Tan

Abstract

Abstract: This review includes for the first time a dynamical systems analysis of human quadrupedalism in Uner Tan syndrome, which is characterized by habitual quadrupedalism, impaired intelligence, and rudimentary speech. The first family was discovered in a small village near Iskenderun, and families were later found in Adana and two other small villages near Gaziantep and Canakkale. In all the affected individuals dynamic balance was impaired during upright walking,and they habitually preferred walking on all four extremities. MRI scans showed inferior cerebellovermian hypoplasia with slightly simplified cerebral gyri in three of the families, but appeared normal in the fourth. PET scans showed a decreased glucose metabolic activity in the cerebellum, vermis and, to a lesser extent the cerebral cortex, except for one patient,\ud whose MRI scan also appeared to be normal. All four families had consanguineous marriages in their pedigrees,\ud suggesting autosomal recessive transmission. The syndrome was genetically heterogeneous. Since the initial discoveries\ud more cases have been found, and these exhibit facultative quadrupedal locomotion, and in one case, late childhood onset. It has been suggested that the human quadrupedalism may, at least, be a phenotypic example of reverse evolution. From the viewpoint of dynamic systems theory, it was concluded there may not be a single factor that predetermines human quadrupedalism in Uner Tan syndrome, but that it may involve self-organization, brain plasticity, and rewiring, from the many decentralized and local interactions among neuronal, genetic, and environmental subsystems

Topics: Behavioral Neuroscience, Brain Imaging, Neurogenetics, Neurology, Neurophysiology, Neuropsychology, Neuropsychiatry
Publisher: Bentham
Year: 2010
OAI identifier: oai:cogprints.org:6939
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    Citations

    1. (1991). A dynamical systems approach to motor development. Phys Ther
    2. (2010). A new case of uner tan syndrome—with late childhood quadrupedalism. Mov Dis
    3. (2006). A new syndrome with quadrupedal gait, primitive speech, and severe mental retardation as a live model for human evolution.
    4. (2009). A new variant of Unertan syndrome: running on all fours in two upright-walking children.
    5. (2001). Arm to leg coordination in humans during walking, creeping and swimming activities. Exp Brain Res
    6. (2005). Autosomal recessive cerebellar hypoplasia in the Hutterite population. Dev Med Child Neurol doi
    7. (2000). Central pattern generators.
    8. (1981). Comparative aspects of primate locomotion with special reference to arboreal cercopithecines. Symp Zool Soc (Lond)
    9. (2006). Coordinated network functioning in the spinal cord: an evolutionary perspective.
    10. (2003). Description, nomenclature, and mapping of a novel cerebello-renal syndrome with the molar tooth malformation. doi
    11. (2003). Development as a dynamic system. Trends Cogn Sci
    12. (2008). Discovery of Unertan syndrome and reverse evolution: as an “Aha!” experience. NeuroQuantology
    13. (1986). Disequilibrium s yndrome in Montana Hutterites. doi
    14. (2002). Do human bipeds use quadrupedal coordination? Trends Neurosci
    15. (1994). Electromyography of back muscles during quadrupedal and bipedal walking in primates.
    16. (1998). Enviromental hypothesis of hominin evolution. Yearb Phys Anthropol
    17. (2006). Evidence for “Unertan Syndrome” and the evolution of the human mind.
    18. (2006). Evidence for “Unertan Syndrome” as a human model for reverse evolution.
    19. (2000). From egg to action.
    20. (2001). Gait initiation in bilateral vestibular loss. Auris Nasus Larynx
    21. (2006). Genetic heterogeneity of autosomal dominant nonprogressive congenital ataxia. Neurology doi
    22. (1999). Hereditary spastic paraplegia: genetic heterogeneity and genotype-phenotype correlation. Semin Neurol doi
    23. (1991). Hidden skills: A dynamic systems analysis of treadmill stepping during the first year. Monogr Soc Res Child Dev
    24. (2005). Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. doi
    25. (2008). Identification of a nonsense mutation in the very low-density lipoprotein receptor gene (VLDLR) in an Iranian family with dysequilibrium syndrome. doi
    26. (1991). Implications of a dynamical systems approach to understanding infant kicking behavior. Phys Ther
    27. (2005). Lateral sequence walking in infant papio cynocephalus: implications for the evolution of diagonal sequence walking in primates.
    28. (1982). Lumbar back muscle activity in relation to trunk movements during locomotion in man. Acta Physiol Scand
    29. (2000). Molecular genetic classification of central nervous system malformations. doi
    30. (2005). Molecular phylogenetics and evolution of turtles. Mol Phylogenet Evol
    31. (1999). Motor patterns in walking. News Physiol Sci
    32. (1998). Non-progressive congenital ataxia with or without cerebellar hypoplasia : a review of 34 subjects. Dev Med Child Neurol doi
    33. (2008). nuture, or chance: stochastic gene expression and its consequences. Cell
    34. (1932). Phylogenie de la locomotion prebipéde de l’homme. Rev Pathol Comp
    35. (2005). Postural control in man: the phylogenetic perspective. Neural Plast
    36. (2008). Self organization. Scholarpedia
    37. (1987). Self-organizing systems and infant motor development. Dev Rev
    38. (2000). The evolution of cortical development. An hypothesis based on the role of the reelin signaling pathway. Trends Neurosci doi
    39. (1936). The evolution of locomotion in mammals.
    40. (1965). The methodology of gait analysis and gaits of monkeys.
    41. (2002). The role of reelin in the development and evolution of the cerebral cortex.
    42. (2001). Tripedal knuckle-walking: a proposal for the evolution of human locomotion and handedness.
    43. (1984). Trunck movements in human locomotion. Acta Physiol Scand
    44. (2006). Tuataras and salamanders show that walking and running mechanics are ancient features of tetrapod locomotion.
    45. (2005). Unertan sendromu ve insan ruhunun evrimine iliskin yeni bir teori. Biyobank
    46. (2005). Unertan syndrome; quadrupedality, primitive language, and severe mental retardation; a new theory on the evolution of human mind. NeuroQuantology
    47. (2008). Unertan Syndrome: review and report of four new cases.
    48. (2008). Unertan Syndrome” in two Turkish families in relation to devolution and emergence of homo erectus: neurological examination, MRI, and PET scans.
    49. (2006). Visualization of a stationary CPG-revealing spinal wave. Stud Health Technol Inform
    50. (2003). Whole-body mechanics and gaits in the gray short-tailed opossum monodelphis domestica: integrating patterns of locomotion in a semi-erect mammal.

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