Location of Repository

Comparative genomics and transcriptional profiles of Saccharopolyspora erythraea NRRL 2338 and a classically improved erythromycin over-producing strain

By Clelia Peano, Adelfia Talà, Giorgio Corti, Daniela Pasanisi, Miriana Durante, Giovanni Mita, Silvio Bicciato, Gianluca De Bellis and Pietro Alifano
Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3359211
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles



    1. (2009). Alifano P: Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutanttype RNA polymerase.
    2. (2010). Alifano P: Guanosine 5’-diphosphate 3’-diphosphate (ppGpp) as a negative modulator of polynucleotide phosphorylase activity in a ‘rare’ actinomycete. Mol Microbiol
    3. (2005). Alifano P: Natural merodiploidy involving duplicated rpoB alleles affects secondary metabolism in a producer actinomycete. Mol Microbiol
    4. (2009). Alifano P: Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production. Microb Cell Fact
    5. (1999). Array of hope.
    6. (2006). Bicciato S: A locally adaptive statistical procedure (LAP) to identify differentially expressed chromosomal regions. Bioinformatics
    7. Biochemical mechanisms in the biosynthesis of the erythromycins.
    8. Byng G: In Manual of Industrial Microbiology and Biotechnology.. 2 edition. Edited by: Demain
    9. (1994). Chater KF: The regulation and integration of antibiotic production and morphological differentiation in Streptomyces spp
    10. (2005). CL: Transcriptional polarity in rRNA operons of Escherichia coli nusA and nusB mutant strains.
    11. (2008). CM: A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea.
    12. (2004). CM: Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. Metab Eng
    13. (1997). Combinatorial approaches to polyketide biosynthesis.
    14. (2010). Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chem Biol
    15. (2006). Demain AL: Genetic improvement of processes yielding microbial products. FEMS Microbiol Rev
    16. (2010). Determination of erythromycins in fermentation broth using liquid phase extraction with back extraction combined with high performance liquid chromatography.
    17. (2006). Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea.
    18. (2007). et al: Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays. Microb Cell Fact
    19. (2007). From microbial differentiation to ribosome engineering.
    20. (2008). Ganoza MC: Interactions of elongation factor EF-P with the Escherichia coli ribosome.
    21. (2001). Genetic methods and strategies for secondary metabolite yield improvement in actinomycetes. Antonie Van Leeuwenhoek
    22. (1978). Goetz JF: HPLC as a rapid means of monitoring erythromycin and tetracycline fermentation processes.
    23. (2005). Hankemeier T: Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets.
    24. (1996). Hood L: Sequence to array: probing the genome’s secrets. Nat Biotechnol
    25. (2000). Hopwood DA: Practical Streptomyces genetics Norwich, England: The John Innes Foundation;
    26. (2004). Impact of ‘ome’ analyses on inverse metabolic engineering. Metab Eng
    27. (2004). JM: Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum. Metab Eng
    28. (1990). JP: Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea.
    29. (2007). JT: The optimal discovery procedure for largescale significance testing, with applications to comparative microarray experiments. Biostatistics
    30. (2007). Khosla C: Antibiotic production from the ground up. Nat Biotechnol
    31. (1991). L: Modular organization of genes required for complex polyketide biosynthesis. Science
    32. (1990). Leadlay PF: An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.
    33. (2007). Leadlay PF: Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat Biotechnol
    34. (1998). Leskiw B: The bldD gene of Streptomyces coelicolor A3(2): a regulatory gene involved in morphogenesis and antibiotic production.
    35. (2001). Leskiw BK: BldD is a direct regulator of key developmental genes in Streptomyces coelicolor A3(2). Mol Microbiol
    36. (1990). Lipman DJ: Basic local alignment search tool.
    37. (1996). Malpartida F: A relA/spoT homologous gene from Streptomyces coelicolor A3(2) controls antibiotic biosynthetic genes.
    38. (2001). Metabolic engineering as an integrating platform for strain development. Curr Opin Microbiol
    39. (1987). Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor.
    40. (1991). MJ: The stringent response in Streptomyces coelicolor A3(2). Mol Microbiol
    41. (2001). Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA
    42. (2009). Ochi K: Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes. Appl Environ Microbiol
    43. (2003). Ochi K: Expression profiling of translation-associated genes in sporulating Bacillus subtilis and consequence of sporulation by gene inactivation. Biosci Biotechnol Biochem
    44. (2007). Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics. Nat Prod Rep
    45. (2011). PREDA: an R-package to identify regional variations in genomic data. Bioinformatics
    46. (2001). Process development and metabolic engineering for the overproduction of natural and unnatural polyketides. Adv Biochem Eng Biotechnol
    47. (2005). RW: Significance analysis of time course microarray experiments.
    48. (2003). Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics
    49. (1993). Staver MJ: IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea. Gene
    50. (2006). Subcellular partitioning of transcription factors in Bacillus subtilis.
    51. (2005). Systems biotechnology for strain improvement. Trends Biotechnol
    52. (2009). TA: Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome. Science
    53. (1993). Tang L: Genetic control of polyketide biosynthesis in the genus Streptomyces. Antonie Van Leeuwenhoek
    54. (2000). The crystal structure of NusB from Mycobacterium tuberculosis. Nat Struct Biol
    55. (1997). The gene encoding the elongation factor P protein is essential for viability and is required for protein synthesis.
    56. (1996). The new genomics: global views of biology. Science
    57. (1997). The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation.
    58. (2003). Tibshirani R: Statistical significance for genomewide studies.
    59. (2008). Transcription by moonlight: structural basis of an extraribosomal activity of ribosomal protein S10. Mol Cell
    60. (1999). Vanden Boom TJ: Transcriptional organization of the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea.
    61. YY: Identifying modules of coexpressed transcript units and their organization of Saccharopolyspora erythraea from time series gene expression profiles.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.