Skip to main content
Article thumbnail
Location of Repository

uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium

By Ceri E Stewart, Hala S Nijmeh, Christopher E Brightling and Ian Sayers
Topics: Asthma
Publisher: BMJ Group
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1997). Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cellbound reactants.
  2. (2010). Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium.
  3. (2007). Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway.
  4. (2008). Dysregulated repair in asthmatic paediatric airway epithelial cells: the role of plasminogen activator inhibitor-1. Clin Exp Allergy
  5. (2003). Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor.
  6. Epithelium dysfunction in asthma. J Allergy Clin Immunol 2007;120:1233e44; quiz 45e6.
  7. (1997). ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction.
  8. (2000). From bronchoconstriction to airways inflammation and remodeling.
  9. (2006). Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.
  10. Gelatinase B is involved in the in vitro wound repair of human respiratory epithelium.
  11. Global guidelines for asthma management: summary of the current status and future challenges. Pol Arch Med Wewn 2010;120:511e17.
  12. (2006). Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.
  13. (2009). Inhalation of urokinase-type plasminogen activator reduces airway remodeling in a murine asthma model.
  14. (1992). Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B. Cancer Res
  15. (1990). Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.
  16. (2006). Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells.
  17. (1997). Involvement of PA/plasmin system in the processing of pro-MMP-9 and in the second step of pro-MMP-2 activation.
  18. (1996). Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells.
  19. (2000). Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology. Adv Cancer Res
  20. (2003). p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades.
  21. (1997). Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin.
  22. (1996). Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2.
  23. (2009). PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline.
  24. (1996). Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.
  25. (2010). Regulation of cell signalling by uPAR. Nat Rev Mol Cell Biol
  26. (2007). Responses of the human airway epithelium transcriptome to in vivo injury. Physiol Genomics
  27. (2009). Role of matrix metalloproteinases in epithelial migration.
  28. (2003). Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling.
  29. (2005). Sputum cathelicidin, urokinase plasminogen activation system components, and cytokines discriminate cystic fibrosis, COPD, and asthma inflammation. Chest
  30. (2002). The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R.
  31. (2008). The fibrinolytic system and the regulation of lung epithelial cell proteolysis, signaling, and cellular viability.
  32. The role of the epithelium in airway remodeling in asthma.
  33. (2010). The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling.
  34. (2001). uPA/plasmin system-mediated MMP-9 activation is implicated in bronchial epithelial cell migration. Exp Cell Res
  35. (2002). uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.