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Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis

By Yi Ye, Berendine van Zyl, Hemlata Varsani, Lucy R. Wedderburn, Athimalaipet Ramanan and Kathleen M. Gillespie


Objective. Recent advances in molecular techniques have revealed that there is bi-directional transfer of cells between mother and child during pregnancy, and the presence of a mother's cells in her child has been termed maternal microchimerism (MMc). There is the potential for maternal cells to provoke inappropriate immune responses in the child, which could be a factor in autoimmunity including JDM. The aim of this study was to determine whether maternal (female) cells could be detected in frozen muscle sections from seven males (age range 3–13 years) with JDM participating in the Juvenile Dermatomyositis National (UK and Ireland) Cohort Biomarker Study and Repository for Idiopathic Inflammatory Myopathies and sections of muscle controls (age range 2–12 years)

Topics: Basic Science
Publisher: Oxford University Press
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Provided by: PubMed Central
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