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Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

By Colin P Kenyon, Robyn L Roth, Chris W van der Westhuyzen and Christopher J Parkinson
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3327638
Provided by: PubMed Central
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    Citations

    1. (1999). AAA+: A class of chaperonin-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res
    2. (2002). Activation mechanism of CDK2: role of cyclin binding versus phosphorylation. Biochemistry
    3. (1980). AJ: Halogenation of tubercidin by Nhalosuccinimides. A direct route to 5-bromotubercidin, a reversible inhibitor of RNA synthesis in eukaryotic cells. Nucl Acid Res
    4. (1995). Bound to activate: conformational consequences of cyclin binding to CDK2. Structure
    5. (2011). Briefly bound to activate: Transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis. Structure
    6. (2008). BVL: Chemoenzymatic synthesis of 7-Deaza cyclic adenosine 5’-diphosphate ribose analogues, membrane-permeant modulators of intracellular calcium release.
    7. (1998). Chapman MS: Transition state structure of arginine kinase: Implications for catalysis of bimolecular reactions.
    8. (2005). Crystal structure of a polyphosphate kinase and its implications for polyphosphate synthesis. EMBO Reports
    9. (2005). Grishin NV: A comprehensive update of the sequence and structure classification of kinases.
    10. (2002). Grishin NV: Sequence and structure classification of kinases.
    11. (1951). HR: The structure of proteins: two hydrogenbonded helical configurations of the polypeptide chain. Proc Natl Acad Sci USA
    12. (1990). Kornberg A: Polyphosphate kinase from Escherichia coli. Purification and demonstration of a phosphoenzyme intermediate.
    13. (2011). LC: The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases.
    14. (2001). Linus: Pauling and the Planar peptide bond.
    15. (1995). Pavletich NPs: Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature
    16. (2003). Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA+ATPase domains. Genes Dev
    17. (1996). S-H: High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: Bound waters and natural ligand as guides for inhibitor design.
    18. (1973). Stotz EH: Enzyme Nomenclature. Comprehensive Biochemistry
    19. (1999). Structure and mechanism in protein science: guide to enzyme catalysis and protein folding
    20. (2010). TB: Engagement of arginine finger to ATP triggers large conformational changes in NtrC1 AAA+ATPase for remodelling bacterial RNA polymerase. Structure

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