Location of Repository

Thalamic Activation Modulates the Responses of Neurons in Rat Primary Auditory Cortex: An In Vivo Intracellular Recording Study

By Lei Han, Yonghai Zhang, Yunxiao Lou and Ying Xiong

Abstract

Auditory cortical plasticity can be induced through various approaches. The medial geniculate body (MGB) of the auditory thalamus gates the ascending auditory inputs to the cortex. The thalamocortical system has been proposed to play a critical role in the responses of the auditory cortex (AC). In the present study, we investigated the cellular mechanism of the cortical activity, adopting an in vivo intracellular recording technique, recording from the primary auditory cortex (AI) while presenting an acoustic stimulus to the rat and electrically stimulating its MGB. We found that low-frequency stimuli enhanced the amplitudes of sound-evoked excitatory postsynaptic potentials (EPSPs) in AI neurons, whereas high-frequency stimuli depressed these auditory responses. The degree of this modulation depended on the intensities of the train stimuli as well as the intervals between the electrical stimulations and their paired sound stimulations. These findings may have implications regarding the basic mechanisms of MGB activation of auditory cortical plasticity and cortical signal processing

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:3325946
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Preview

    Citations

    1. (2005). A new stabilizing craniotomy–duratomy technique for singlecell anatomo-electrophysiological exploration of living intact brain networks.
    2. (2007). A synaptic memory trace for cortical receptive field plasticity.
    3. (1998). Activity-dependent scaling of quantal amplitude in neocortical neurons.
    4. (2004). Adaptation changes the direction tuning of macaque MT neurons.
    5. (2004). Adaptation in thalamic barreloid and cortical barrel neurons to periodic whisker deflections varying in frequency and velocity.
    6. (2008). Adaptive coding of visual information in neural populations.
    7. (2009). An analysis of the transitions between down and up states of the cortical slow oscillation under urethane anaesthesia.
    8. (2002). Auditory thalamocortical synaptic transmission in vitro.
    9. (2005). Auditory thalamocortical transformation: structure and function.
    10. (2005). Auditory thalamocortical transmission is reliable and temporally precise.
    11. (2004). Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition.
    12. (2006). Cellular mechanisms preventing sustained activation of cortex during subcortical high-frequency stimulation.
    13. (2003). Characterisation of multiple physiological fields within the anatomical core of rat auditory cortex.
    14. (2011). Contributions of the thalamocortical system towards sound-specific auditory plasticity.
    15. (2006). Cortex Is Driven by Weak but Synchronously Active Thalamocortical Synapses.
    16. (2004). Corticofugal gating of auditory information in the thalamus: an in vivo intracellular recording study.
    17. (2008). Corticothalamic feedback for sound-specific plasticity of auditory thalamic neurons elicited by tones paired with basal forebrain stimulation.
    18. (2001). Dynamics of spontaneous activity in neocortical slices.
    19. (2011). Effects of acoustic stimuli on neuronal activity in the auditory cortex of the rat.
    20. (2004). Effects of cortical stimulation on auditory-responsive thalamic neurones in anaesthetized guinea pigs.
    21. (2010). Effects of thalamic highfrequency electrical stimulation on whisker-evoked cortical adaptation.
    22. (1996). Evolution of GABAergic circuitry in the mammalian medial geniculate body.
    23. (2010). Fine-tuning of prebalanced excitation and inhibition during auditory cortical development.
    24. (2001). Functional convergence of response properties in the auditory thalamocortical system.
    25. (2007). Heterosynaptic facilitation of in vivo thalamocortical long-term potentiation in the adult rat visual cortex by acetylcholine.
    26. (2009). Impact of persistent cortical activity (up States) on intracortical and thalamocortical synaptic inputs.
    27. (2011). Interplay of excitation and inhibition elicited by tonal stimulation in pyramidal neurons of primary auditory cortex.
    28. (2002). Intracellular characterization of suppressive responses in supragranular pyramidal neurons of cat primary auditory cortex in vivo.
    29. (1994). Laminar distribution and neuronal targets of GABAergic axon terminals in cat primary auditory cortex (AI).
    30. (1998). Long-term depression at thalamocortical synapses in developing rat somatosensory cortex.
    31. (2001). Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo.
    32. (2007). Modulation of the receptive fields of midbrain neurons elicited by thalamic electrical stimulation through corticofugal feedback.
    33. (1983). Morel A
    34. (2007). Multiparametric changes in the receptive field of cortical auditory neurons induced by thalamic activation in the mouse.
    35. (2008). Neural coding of temporal information in auditory thalamus and cortex.
    36. (1993). Nucleus basalis stimulation facilitates thalamocortical synaptic transmission in the rat auditory cortex.
    37. (1988). Organization of auditory cortex in the albino rat: sound frequency.
    38. (2010). Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons.
    39. (2009). Postsynaptic mechanisms govern the differential excitation of cortical neurons by thalamic inputs.
    40. (2002). Redefining the tonotopic core of rat auditory cortex: physiological evidence for a posterior field.
    41. (2006). Reduction of information redundancy in the ascending auditory pathway.
    42. (2006). Relief of synaptic depression produces long-term enhancement in thalamocortical networks.
    43. (2008). Role of corticofugal feedback in hearing.
    44. (1998). Role of thalamic and cortical neurons in augmenting responses and self-sustained activity: dual intracellular recordings in vivo.
    45. (2002). Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo.
    46. (2005). Short-term depression in thalamocortical synapses of cat primary visual cortex.
    47. (2007). Short-term plasticity in auditory cognition.
    48. (2001). Short-term synaptic plasticity as a temporal filter.
    49. (2009). Specific and nonspecific plasticity of the primary auditory cortex elicited by thalamic auditory neurons.
    50. (2005). Spectral integration in auditory cortex: mechanisms and modulation.
    51. (2007). Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex.
    52. (1997). Synaptic depression and cortical gain control.
    53. (2004). Synaptic interactions between thalamic and cortical inputs onto cortical neurons in vivo.
    54. (1999). Synaptic plasticity at thalamocortical synapses in developing rat somatosensory cortex: LTP, LTD, and silent synapses.
    55. (2012). Thalamic control of cortical states.
    56. (2007). The action potential in mammalian central neurons.
    57. (2011). The ongoing balance of cortical excitation and inhibition during early development.
    58. (1998). The rat brain in stereotaxic coordinates.
    59. (2002). The role of the thalamus in the flow of information to the cortex.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.