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Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels

By Marcel H. Schulz, Daniel R. Zerbino, Martin Vingron and Ewan Birney

Abstract

Motivation: High-throughput sequencing has made the analysis of new model organisms more affordable. Although assembling a new genome can still be costly and difficult, it is possible to use RNA-seq to sequence mRNA. In the absence of a known genome, it is necessary to assemble these sequences de novo, taking into account possible alternative isoforms and the dynamic range of expression values

Topics: Original Papers
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:3324515
Provided by: PubMed Central
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