Skip to main content
Article thumbnail
Location of Repository

Chemokine Receptor 5 Δ32 Allele in Patients with Severe Pandemic (H1N1) 2009

By Yoav Keynan, Jennifer Juno, Adrienne Meyers, T. Blake Ball, Anand Kumar, Ethan Rubinstein and Keith R. Fowke

Abstract

Because chemokine receptor 5 (CCR5) may have a role in pulmonary immune response, we explored whether patients with severe pandemic (H1N1) 2009 were more likely to carry the CCR5Δ32 allele than were members of the general population. We found a large proportion of heterozygosity for the CCR5Δ32 allele among white patients with severe disease

Topics: Dispatch
Publisher: Centers for Disease Control and Prevention
OAI identifier: oai:pubmedcentral.nih.gov:3294998
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2008). A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis. J Infect Dis.
    2. (2008). Case of yellow fever vaccine–associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. J Infect Dis.
    3. CCR5 defi ciency increases risk of symptomatic West Nile virus infection.
    4. Chemokine receptor CCR5 promotes leukocyte traffi cking to the brain and survival in West Nile virus infection.
    5. Contrasting effects of CCR5 and CCR2 defi ciency in the pulmonary infl ammatory response to infl uenza A virus.
    6. Effects of CCR5-delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection.
    7. (2008). Genetic defi ciency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic. J Infect Dis.
    8. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection.
    9. (2004). Prevalence of chemokine and chemokine receptor polymorphisms in seroprevalent children with symptomatic HIV-1 infection in the United States. J Acquir Immune Defi c Syndr.
    10. (2010). Regional variation in CCR5-delta32 gene distribution among women from the
    11. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
    12. The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.