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Disambiguating ventral striatum fMRI-related bold signal during reward prediction in schizophrenia

By R W Morris, A Vercammen, R Lenroot, L Moore, J M Langton, B Short, J Kulkarni, J Curtis, M O'Donnell, C S Weickert and T W Weickert

Abstract

Reward detection, surprise detection and prediction-error signaling have all been proposed as roles for the ventral striatum (vStr). Previous neuroimaging studies of striatal function in schizophrenia have found attenuated neural responses to reward-related prediction errors; however, as prediction errors represent a discrepancy in mesolimbic neural activity between expected and actual events, it is critical to examine responses to both expected and unexpected rewards (URs) in conjunction with expected and UR omissions in order to clarify the nature of ventral striatal dysfunction in schizophrenia. In the present study, healthy adults and people with schizophrenia were tested with a reward-related prediction-error task during functional magnetic resonance imaging to determine whether schizophrenia is associated with altered neural responses in the vStr to rewards, surprise prediction errors or all three factors. In healthy adults, we found neural responses in the vStr were correlated more specifically with prediction errors than to surprising events or reward stimuli alone. People with schizophrenia did not display the normal differential activation between expected and URs, which was partially due to exaggerated ventral striatal responses to expected rewards (right vStr) but also included blunted responses to unexpected outcomes (left vStr). This finding shows that neural responses, which typically are elicited by surprise, can also occur to well-predicted events in schizophrenia and identifies aberrant activity in the vStr as a key node of dysfunction in the neural circuitry used to differentiate expected and unexpected feedback in schizophrenia

Topics: Original Article
Publisher: Nature Publishing Group
OAI identifier: oai:pubmedcentral.nih.gov:3284694
Provided by: PubMed Central
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    Citations

    1. (1997). A neural substrate of prediction and reward. Science
    2. (1992). Abolition of latent inhibition by a single 5 mg dose of d-amphetamine in man. Psychopharmacology (Berl)
    3. (2010). Altered activation in association with reward-related trial-and-error learning in patients with schizophrenia. Neuroimage
    4. (2009). Altered reward functions in patients on atypical antipsychotic medication in line with the revised dopamine hypothesis of schizophrenia. Psychopharmacology (Berl)
    5. (1998). Anterior cingulate cortex, error detection, and the online monitoring of performance. Science
    6. (2008). Atlas of the Human Brain, 3rd edn. Elsevier:
    7. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage
    8. (2008). BOLD responses reflecting dopaminergic signals in the human ventral tegmental area. Science
    9. (2003). Chlorpromazine equivalent doses for the newer atypical antipsychotics.
    10. (2003). Coding of predicted reward omission by dopamine neurons in a conditioned inhibition paradigm.
    11. (2003). Controlling the familywise error rate in functional neuroimaging: a comparative review. Stat Meth Med Res
    12. (2008). Dialogues on prediction errors. Trends Cogn Sci
    13. Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors.
    14. (2008). Dopamine and reward: the anhedonia hypothesis 30 years on. Neurotox Res
    15. (2009). Dopaminergic modulation of appetitive and aversive predictive learning. Rev Neurosci
    16. (2004). Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals.
    17. (2006). Dysfunction of ventral striatal reward prediction in schizophrenia. Neuroimage
    18. (2009). Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Arch Gen Psychiatry
    19. (2010). Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions.
    20. (2002). Habit and skill learning in schizophrenia: evidence of normal striatal processing with abnormal cortical input. Learn Mem
    21. (2010). Herna ´ndez AI, Martı ´nCet al. Subcortical and cortical gray matter differences between Kraepelinian and non-Kraepelinian schizophrenia patients identified using voxel-based morphometry. Psychiatry Res
    22. (2001). Impaired associative learning in chronic schizophrenics and their first-degree relatives: a study of latent inhibition and the Kamin blocking effect. Schizophr Res
    23. (2010). Increased synaptic dopamine function in associative regions of the striatum in schizophrenia. Arch Gen Psychiatry
    24. (1998). Integrating schizophrenia. Schizophr Bull
    25. (2009). Neural correlates of probabilistic category learning in patients with schizophrenia.
    26. (2010). Neural correlates of reward processing in schizophrenia – relationship to apathy and depression. Schizophrenia Res
    27. (2000). Neuronal coding of prediction errors. Annu Rev Neurosci
    28. (2003). New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. Lancet
    29. (2006). Opioid receptors in the nucleus accumbens regulate attentional learning in the blocking paradigm.
    30. (2009). Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers. Neuropsychopharmacology
    31. (2001). Predictability modulates human brain response to reward.
    32. (2006). prediction error and associative learning: a model-based account. Network
    33. (2007). Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction. Schizophr Res
    34. (2003). Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia.
    35. (2008). Reward processing in schizophrenia: a deficit in the representation of value. Schizophr Bull
    36. (2008). Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine. Psychopharmacology (Berl)
    37. (2007). Sensitivity of the nucleus accumbens to violations in expectation of reward. Neuroimage
    38. (2007). Structured Clinical Interview for DSM-IV-TR Axis I Disorders—Patient Edition, 1st revision edn. Biometrics Research Department:
    39. (2003). Temporal difference models and reward-related learning in the human brain. Neuron
    40. (2003). Temporal prediction errors in a passive learning task activate human striatum. Neuron
    41. Testing the reward prediction error hypothesis with an axiomatic model.
    42. (2008). The formation of abnormal associations in schizophrenia: neural and behavioral evidence. Neuropsychopharmacology
    43. (2002). The neural basis of human error processing: reinforcement learning, dopamine, and the errorrelated negativity. Psychol Rev
    44. (1991). The neuropsychology of schizophrenia.
    45. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
    46. (2010). The relevance of reward pathways for schizophrenia. Curr Opin Psychiatry
    47. (2002). Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage
    48. (2006). Ventral-striatal/nucleusaccumbens sensitivity to prediction errors during classification learning. Hum Brain Mapp
    49. (2006). Villringer A et al. Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics. Psychopharmacology (Berl)
    50. (1997). Wechsler Adult Intelligence Scale, 3rd edn. The Psychological Corporation:
    51. (2001). Wechsler Test of Adult Reading. The Psychological Corporation:

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