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CD163 versus CD68 in tumor associated macrophages of classical hodgkin lymphoma

By Jonathan A Harris, Salvia Jain, Qinghu Ren, Alirezah Zarineh, Cynthia Liu and Sherif Ibrahim

Abstract

Classical Hodgkin lymphoma (CHL) is a B-cell lymphoproliferative disorder with a relatively good prognosis. A small but significant percentage of patients, however, will respond poorly to therapy. A recent gene expression profiling study has identified a macrophage signature which has been correlated with primary treatment failure, and immunohistochemical tissue microarray for CD68 was shown to reflect the gene signature as a potentially clinically useful marker to predict adverse prognosis

Topics: Research
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:3281786
Provided by: PubMed Central
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